HSP90 inhibitors decrease AID levels and activity in mice and in human cells

Activation induced deaminase (AID) initiates somatic hypermutation and class switch recombination of the Ig genes in antigen-activated B cells, underpinning antibody affinity maturation and isotype switching. AID can also be pathogenic by contributing to autoimmune diseases and oncogenic mutations....

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發表在:Eur J Immunol
Main Authors: Montamat-Sicotte, Damien, Liztler, Ludivine C, Abreu, Cecilia, Safavi, Shiva, Zahn, Astrid, Orthwein, Alexandre, Muschen, Markus, Oppezzo, Pablo, Muñoz, Denise P, Di Noia, Javier M
格式: Artigo
語言:Inglês
出版: 2015
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4536124/
https://ncbi.nlm.nih.gov/pubmed/25912253
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/eji.201545462
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