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UNG protects B cells from AID-induced telomere loss
Activation-induced deaminase (AID) initiates antibody gene diversification by creating G:U mismatches in the immunoglobulin loci. However, AID also deaminates nonimmunoglobulin genes, and failure to faithfully repair these off-target lesions can cause B cell lymphoma. In this study, we identify a me...
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| Publicado no: | J Exp Med |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Rockefeller University Press
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5068241/ https://ncbi.nlm.nih.gov/pubmed/27697833 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20160635 |
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