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Cyclin-Dependent Kinases Regulate Ig Class Switching by Controlling Access of AID to the Switch Region
Ig class switching requires cell proliferation and is division linked, but the detailed mechanism is unknown. By analyzing the first switching cells early in the kinetics, our analysis suggested that proliferating B cells had a very short G(1) phase (<3.5 h), a total cell cycle time of ∼11 h, and...
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| Publicado no: | J Immunol |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
AAI
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4400815/ https://ncbi.nlm.nih.gov/pubmed/25795757 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1402146 |
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