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Cyclin-Dependent Kinases Regulate Ig Class Switching by Controlling Access of AID to the Switch Region
Ig class switching requires cell proliferation and is division linked, but the detailed mechanism is unknown. By analyzing the first switching cells early in the kinetics, our analysis suggested that proliferating B cells had a very short G(1) phase (<3.5 h), a total cell cycle time of ∼11 h, and...
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| Pubblicato in: | J Immunol |
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| Autori principali: | , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
AAI
2015
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4400815/ https://ncbi.nlm.nih.gov/pubmed/25795757 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1402146 |
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