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HSP90 inhibitors decrease AID levels and activity in mice and in human cells
Activation induced deaminase (AID) initiates somatic hypermutation and class switch recombination of the Ig genes in antigen-activated B cells, underpinning antibody affinity maturation and isotype switching. AID can also be pathogenic by contributing to autoimmune diseases and oncogenic mutations....
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| Publicado no: | Eur J Immunol |
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| Main Authors: | , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4536124/ https://ncbi.nlm.nih.gov/pubmed/25912253 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/eji.201545462 |
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