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Daxx, a Novel Fas-Binding Protein That Activates JNK and Apoptosis

The Fas cell surface receptor induces apoptosis upon receptor oligomerization. We have identified a novel signaling protein, termed Daxx, that binds specifically to the Fas death domain. Overexpression of Daxx enhances Fas-mediated apoptosis and activates the Jun N-terminal kinase (JNK) pathway. A C...

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Autors principals: Yang, Xiaolu, Khosravi-Far, Roya, Chang, Howard Y., Baltimore, David
Format: Artigo
Idioma:Inglês
Publicat: 1997
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2989411/
https://ncbi.nlm.nih.gov/pubmed/9215629
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