A novel Fas-binding outer membrane protein and lipopolysaccharide of Leptospira interrogans induce macrophage apoptosis through the Fas/FasL-caspase-8/-3 pathway

Leptospira interrogans is the major causative agent of leptospirosis, an emerging, globally spreading zoonotic infectious disease. The pathogen induces macrophage apoptosis, but the molecular basis and mechanism remain unknown. In the present study, we found that L. interrogans caused apoptosis of p...

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Bibliographic Details
Published in:Emerg Microbes Infect
Main Authors: Du, Peng, Li, Shi-Jun, Ojcius, David M., Li, Kai-Xuan, Hu, Wei-Lin, Lin, Xu’ai, Sun, Ai-Hua, Yan, Jie
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2018
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6066479/
https://ncbi.nlm.nih.gov/pubmed/30061622
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41426-018-0135-9
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