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Dissecting Fas signaling with an altered-specificity death-domain mutant: Requirement of FADD binding for apoptosis but not Jun N-terminal kinase activation

Fas is a cell surface death receptor that regulates peripheral tolerance and lymphoid homeostasis. In many pathologic conditions, ectopic Fas activation mediates tissue destruction. Several proteins that can bind to the cytoplasmic death domain of Fas have been implicated in Fas signal transduction....

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Bibliografische gegevens
Hoofdauteurs: Chang, Howard Y., Yang, Xiaolu, Baltimore, David
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: The National Academy of Sciences 1999
Onderwerpen:
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC15449/
https://ncbi.nlm.nih.gov/pubmed/9990010
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