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4-Hydroxynonenal self-limits Fas-mediated DISC independent apoptosis by promoting export of Daxx from nucleus to cytosol and its binding to Fas

Previously, we have shown that 4-hydroxynonenal (4-HNE) induces Fas-mediated apoptosis in HLE B-3 cells through a pathway which is independent of FasL, FADD, procaspase8-and DISC (Li, J. et al. Biochemistry, 45, 12253-12264). The involvement of Daxx has also been suggested in this pathway but its ro...

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Hlavní autoři: Sharma, Rajendra, Sharma, Abha, Dwivedi, Seema, Zimniak, Piotr, Awasthi, Sanjay, Awasthi, Yogesh C.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2007
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2564820/
https://ncbi.nlm.nih.gov/pubmed/18069800
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi701559f
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