4-Hydroxynonenal Induces G(2)/M Phase Cell Cycle Arrest by Activation of the Ataxia Telangiectasia Mutated and Rad3-related Protein (ATR)/Checkpoint Kinase 1 (Chk1) Signaling Pathway

4-Hydroxynonenal (HNE) has been widely implicated in the mechanisms of oxidant-induced toxicity, but the detrimental effects of HNE associated with DNA damage or cell cycle arrest have not been thoroughly studied. Here we demonstrate for the first time that HNE caused G(2)/M cell cycle arrest of hep...

Descrición completa

Gardado en:
Detalles Bibliográficos
Main Authors: Chaudhary, Pankaj, Sharma, Rajendra, Sahu, Mukesh, Vishwanatha, Jamboor K., Awasthi, Sanjay, Awasthi, Yogesh C.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2013
Assuntos:
Signal Transduction
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3711318/
https://ncbi.nlm.nih.gov/pubmed/23733185
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.467662
Tags: Engadir etiqueta
Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!

Títulos similares