4-Hydroxynonenal Induces G(2)/M Phase Cell Cycle Arrest by Activation of the Ataxia Telangiectasia Mutated and Rad3-related Protein (ATR)/Checkpoint Kinase 1 (Chk1) Signaling Pathway

4-Hydroxynonenal (HNE) has been widely implicated in the mechanisms of oxidant-induced toxicity, but the detrimental effects of HNE associated with DNA damage or cell cycle arrest have not been thoroughly studied. Here we demonstrate for the first time that HNE caused G(2)/M cell cycle arrest of hep...

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Detalhes bibliográficos
Main Authors: Chaudhary, Pankaj, Sharma, Rajendra, Sahu, Mukesh, Vishwanatha, Jamboor K., Awasthi, Sanjay, Awasthi, Yogesh C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2013
Assuntos:
Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3711318/
https://ncbi.nlm.nih.gov/pubmed/23733185
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.467662
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