Dbf4 Is Direct Downstream Target of Ataxia Telangiectasia Mutated (ATM) and Ataxia Telangiectasia and Rad3-related (ATR) Protein to Regulate Intra-S-phase Checkpoint

Dbf4/Cdc7 (Dbf4-dependent kinase (DDK)) is activated at the onset of S-phase, and its kinase activity is required for DNA replication initiation from each origin. We showed that DDK is an important target for the S-phase checkpoint in mammalian cells to suppress replication initiation and to protect...

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Detalhes bibliográficos
Main Authors: Lee, Alan Yueh-Luen, Chiba, Takuya, Truong, Lan N., Cheng, An Ning, Do, Johnny, Cho, Michael Jeffrey, Chen, Longchuan, Wu, Xiaohua
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
DNA and Chromosomes
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3268413/
https://ncbi.nlm.nih.gov/pubmed/22123827
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.291104
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