Dbf4 Is Direct Downstream Target of Ataxia Telangiectasia Mutated (ATM) and Ataxia Telangiectasia and Rad3-related (ATR) Protein to Regulate Intra-S-phase Checkpoint

Dbf4/Cdc7 (Dbf4-dependent kinase (DDK)) is activated at the onset of S-phase, and its kinase activity is required for DNA replication initiation from each origin. We showed that DDK is an important target for the S-phase checkpoint in mammalian cells to suppress replication initiation and to protect...

Celý popis

Uloženo v:
Podrobná bibliografie
Hlavní autoři: Lee, Alan Yueh-Luen, Chiba, Takuya, Truong, Lan N., Cheng, An Ning, Do, Johnny, Cho, Michael Jeffrey, Chen, Longchuan, Wu, Xiaohua
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2012
Témata:
DNA and Chromosomes
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3268413/
https://ncbi.nlm.nih.gov/pubmed/22123827
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.291104
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky