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The ATR-mediated S phase checkpoint prevents rereplication in mammalian cells when licensing control is disrupted
DNA replication in eukaryotic cells is tightly controlled by a licensing mechanism, ensuring that each origin fires once and only once per cell cycle. We demonstrate that the ataxia telangiectasia and Rad3 related (ATR)–mediated S phase checkpoint acts as a surveillance mechanism to prevent rereplic...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Rockefeller University Press
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2080923/ https://ncbi.nlm.nih.gov/pubmed/18025301 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200704138 |
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