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An ATR- and BRCA1-Mediated Fanconi Anemia Pathway Is Required for Activating the G(2)/M Checkpoint and DNA Damage Repair upon Rereplication
The timely assembly of prereplicative complexes at replication origins is tightly controlled to ensure that genomic DNA is replicated once per cell cycle. The loss of geminin, a DNA replication inhibitor, causes rereplication that activates a G(2)/M checkpoint in human cancer cells. Fanconi anemia (...
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| Autors principals: | , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
American Society for Microbiology
2006
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1489121/ https://ncbi.nlm.nih.gov/pubmed/16738325 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.02141-05 |
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