Clinicopathological significance of ataxia telangiectasia-mutated (ATM) kinase and ataxia telangiectasia-mutated and Rad3-related (ATR) kinase in MYC overexpressed breast cancers

PURPOSE: MYC transcription factor has critical roles in cell growth, proliferation, metabolism, differentiation, transformation and angiogenesis. MYC overexpression is seen in about 15% of breast cancers and linked to aggressive phenotypes. MYC overexpression also induces oxidative stress and replic...

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Detalhes bibliográficos
Publicado no:Breast Cancer Res Treat
Main Authors: Savva, Constantinos, De Souza, Karen, Ali, Reem, Rakha, Emad A., Green, Andrew R., Madhusudan, Srinivasan
Formato: Artigo
Idioma:Inglês
Publicado em: Springer US 2019
Assuntos:
Preclinical Study
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6491658/
https://ncbi.nlm.nih.gov/pubmed/30746633
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10549-018-05113-8
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