Ataxia Telangiectasia Mutated and Rad3 Related (ATR) Protein Kinase Inhibition Is Synthetically Lethal in XRCC1 Deficient Ovarian Cancer Cells

INTRODUCTION: Ataxia telangiectasia mutated and Rad3 Related (ATR) protein kinase is a key sensor of single-stranded DNA associated with stalled replication forks and repair intermediates generated during DNA repair. XRCC1 is a critical enzyme in single strand break repair and base excision repair....

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Главные авторы: Sultana, Rebeka, Abdel-Fatah, Tarek, Perry, Christina, Moseley, Paul, Albarakti, Nada, Mohan, Vivek, Seedhouse, Claire, Chan, Stephen, Madhusudan, Srinivasan
Формат: Artigo
Язык:Inglês
Опубликовано: Public Library of Science 2013
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Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3581581/
https://ncbi.nlm.nih.gov/pubmed/23451157
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0057098
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