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Graded enhancement of p53 binding to CREB-binding protein (CBP) by multisite phosphorylation

The transcriptional activity of p53 is regulated by a cascade of posttranslational modifications. Although acetylation of p53 by CREB-binding protein (CBP)/p300 is known to be indispensable for p53 activation, the role of phosphorylation, and in particular multisite phosphorylation, in activation of...

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Detalles Bibliográficos
Main Authors: Lee, Chul Won, Ferreon, Josephine C., Ferreon, Allan Chris M., Arai, Munehito, Wright, Peter E.
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2010
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2984141/
https://ncbi.nlm.nih.gov/pubmed/20962272
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1013078107
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