Development of a Validated Immunofluorescence Assay for γH2AX as a Pharmacodynamic Marker of Topoisomerase I Inhibitor Activity

PURPOSE: Phosphorylated histone H2AX (γH2AX) serves as a biomarker for formation of DNA double-strand break repair complexes. A quantitative pharmacodynamic immunofluorescence assay for γH2AX was developed, validated, and tested in human tumor xenograft models using clinically relevant procedures. E...

Full beskrivning

Sparad:
Bibliografiska uppgifter
Huvudupphovsmän: Kinders, Robert J., Hollingshead, Melinda, Lawrence, Scott, Ji, Jiuping, Tabb, Brian, Bonner, William M., Pommier, Yves, Rubinstein, Larry, Evrard, Yvonne A., Parchment, Ralph E., Tomaszewski, Joseph, Doroshow, James H.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2010
Ämnen:
Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2982895/
https://ncbi.nlm.nih.gov/pubmed/20924131
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-09-3076
Taggar: Lägg till en tagg
Inga taggar, Lägg till första taggen!

Liknande verk