Automated High-Content Live Animal Drug Screening Using C. elegans Expressing the Aggregation Prone Serpin α1-antitrypsin Z

The development of preclinical models amenable to live animal bioactive compound screening is an attractive approach to discovering effective pharmacological therapies for disorders caused by misfolded and aggregation-prone proteins. In general, however, live animal drug screening is labor and resou...

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Bibliografiske detaljer
Main Authors: Gosai, Sager J., Kwak, Joon Hyeok, Luke, Cliff J., Long, Olivia S., King, Dale E., Kovatch, Kevin J., Johnston, Paul A., Shun, Tong Ying, Lazo, John S., Perlmutter, David H., Silverman, Gary A., Pak, Stephen C.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2010
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2980495/
https://ncbi.nlm.nih.gov/pubmed/21103396
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0015460
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