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α1-antitrypsin deficiency and the hepatocytes - an elegans solution to drug discovery
Hepatocytes are metabolically active cells of the liver that play an important role in the biosynthesis of proteins including α1-antitrypsin. Mutations in the α1-antitrypsin gene can lead to protein misfolding, polymerization/aggregation and retention of protein within the endoplasmic reticulum of h...
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| Autori principali: | , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2013
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3970812/ https://ncbi.nlm.nih.gov/pubmed/24355812 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biocel.2013.12.006 |
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