A genome-wide RNAi screen identifies potential drug targets in a C. elegans model of α1-antitrypsin deficiency

α1-Antitrypsin deficiency (ATD) is a common genetic disorder that can lead to end-stage liver and lung disease. Although liver transplantation remains the only therapy currently available, manipulation of the proteostasis network (PN) by small molecule therapeutics offers great promise. To accelerat...

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Autors principals: O'Reilly, Linda P., Long, Olivia S., Cobanoglu, Murat C., Benson, Joshua A., Luke, Cliff J., Miedel, Mark T., Hale, Pamela, Perlmutter, David H., Bahar, Ivet, Silverman, Gary A., Pak, Stephen C.
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2014
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Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4159156/
https://ncbi.nlm.nih.gov/pubmed/24838285
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddu236
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