A C. elegans model of human α1-antitrypsin deficiency links components of the RNAi pathway to misfolded protein turnover

The accumulation of serpin oligomers and polymers within the endoplasmic reticulum (ER) causes cellular injury in patients with the classical form α1-antitrypsin deficiency (ATD). To better understand the cellular and molecular genetic aspects of this disorder, we generated transgenic C. elegans str...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Long, Olivia S., Benson, Joshua A., Kwak, Joon Hyeok, Luke, Cliff J., Gosai, Sager J., O'Reilly, Linda P., Wang, Yan, Li, Jie, Vetica, Anne C., Miedel, Mark T., Stolz, Donna B., Watkins, Simon C., Züchner, Stephan, Perlmutter, David H., Silverman, Gary A., Pak, Stephen C.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2014
Assuntos:
Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4159155/
https://ncbi.nlm.nih.gov/pubmed/24838286
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddu235
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados