Structural Basis for the cAMP-dependent Gating in the Human HCN4 Channel

Hyperpolarization-activated cAMP-regulated (HCN) channels play important physiological roles in both cardiovascular and central nervous systems. Among the four HCN isoforms, HCN2 and HCN4 show high expression levels in the human heart, with HCN4 being the major cardiac isoform. The previously publis...

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Bibliographische Detailangaben
Hauptverfasser: Xu, Xinping, Vysotskaya, Zhanna V., Liu, Qinglian, Zhou, Lei
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2010
Schlagworte:
Molecular Biophysics
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2978636/
https://ncbi.nlm.nih.gov/pubmed/20829353
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.152033
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