Inner activation gate in S6 contributes to the state-dependent binding of cAMP in full-length HCN2 channel

Recently, applications of the patch-clamp fluorometry (PCF) technique in studies of cyclic nucleotide–gated (CNG) and hyperpolarization-activated, cyclic nucleotide–regulated (HCN) channels have provided direct evidence for the long-held notion that ligands preferably bind to and stabilize these cha...

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Detalhes bibliográficos
Main Authors: Wu, Shengjun, Gao, Weihua, Xie, Changan, Xu, Xinping, Vorvis, Christina, Marni, Farzana, Hackett, Amber R., Liu, Qinglian, Zhou, Lei
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3382721/
https://ncbi.nlm.nih.gov/pubmed/22689828
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.201110749
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