Structural Basis for the cAMP-dependent Gating in the Human HCN4 Channel

Hyperpolarization-activated cAMP-regulated (HCN) channels play important physiological roles in both cardiovascular and central nervous systems. Among the four HCN isoforms, HCN2 and HCN4 show high expression levels in the human heart, with HCN4 being the major cardiac isoform. The previously publis...

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Bibliographic Details
Main Authors: Xu, Xinping, Vysotskaya, Zhanna V., Liu, Qinglian, Zhou, Lei
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2010
Subjects:
Molecular Biophysics
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2978636/
https://ncbi.nlm.nih.gov/pubmed/20829353
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.152033
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