Inhibition of Bak Activation by VDAC2 Is Dependent on the Bak Transmembrane Anchor

Bax and Bak are pro-apoptotic factors that are required for cell death by the mitochondrial or intrinsic pathway. Bax is found in an inactive state in the cytosol and upon activation is targeted to the mitochondrial outer membrane where it releases cytochrome c and other factors that cause caspase a...

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Bibliografiska uppgifter
Huvudupphovsmän: Lazarou, Michael, Stojanovski, Diana, Frazier, Ann E., Kotevski, Aneta, Dewson, Grant, Craigen, William J., Kluck, Ruth M., Vaux, David L., Ryan, Michael T.
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Biochemistry and Molecular Biology 2010
Ämnen:
Cell Biology
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2978617/
https://ncbi.nlm.nih.gov/pubmed/20851889
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.159301
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