Requirement of TGFβ Signaling for SMO-mediated Carcinogenesis

Hedgehog (Hh) signaling, via the key signal transducer Smoothened (SMO) and Gli transcription factors, is essential for embryonic development and carcinogenesis. At present, the molecular mechanism of Hh signaling-mediated carcinogenesis is not completely understood. Using a mouse model (K14cre/R26S...

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Autores principales: Fan, Qipeng, He, Miao, Sheng, Tao, Zhang, Xiaoli, Sinha, Mala, Luxon, Bruce, Zhao, Xingbo, Xie, Jingwu
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2010
Materias:
Signal Transduction
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2978585/
https://ncbi.nlm.nih.gov/pubmed/20858897
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.C110.164442
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