Requirement of TGFβ Signaling for SMO-mediated Carcinogenesis

Hedgehog (Hh) signaling, via the key signal transducer Smoothened (SMO) and Gli transcription factors, is essential for embryonic development and carcinogenesis. At present, the molecular mechanism of Hh signaling-mediated carcinogenesis is not completely understood. Using a mouse model (K14cre/R26S...

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Dades bibliogràfiques
Autors principals: Fan, Qipeng, He, Miao, Sheng, Tao, Zhang, Xiaoli, Sinha, Mala, Luxon, Bruce, Zhao, Xingbo, Xie, Jingwu
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2010
Matèries:
Signal Transduction
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2978585/
https://ncbi.nlm.nih.gov/pubmed/20858897
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.C110.164442
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