Requirement of TGFβ Signaling for SMO-mediated Carcinogenesis

Hedgehog (Hh) signaling, via the key signal transducer Smoothened (SMO) and Gli transcription factors, is essential for embryonic development and carcinogenesis. At present, the molecular mechanism of Hh signaling-mediated carcinogenesis is not completely understood. Using a mouse model (K14cre/R26S...

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Bibliografiske detaljer
Main Authors: Fan, Qipeng, He, Miao, Sheng, Tao, Zhang, Xiaoli, Sinha, Mala, Luxon, Bruce, Zhao, Xingbo, Xie, Jingwu
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2010
Fag:
Signal Transduction
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2978585/
https://ncbi.nlm.nih.gov/pubmed/20858897
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.C110.164442
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