Defective TGFβ signaling in bone marrow-derived cells prevents Hedgehog-induced skin tumors

Hedgehog (Hh) signaling in cancer cells drives changes in the tumor microenvironment that are incompletely understood. Here we report that Hh- driven tumors exhibit an increase in myeloid-derived suppressor cells (MDSC) and a decrease in T cells, indicative of an immune suppressive tumor microenviro...

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Главные авторы: Fan, Qipeng, Gu, Dongsheng, Liu, Hailan, Yang, Ling, Zhang, Xiaoli, Yoder, Mervin C., Kaplan, Mark H., Xie, Jingwu
Формат: Artigo
Язык:Inglês
Опубликовано: 2013
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3963525/
https://ncbi.nlm.nih.gov/pubmed/24282281
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-13-2134-T
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