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Design, Synthesis and In Vitro Evaluation of Potential West Nile Virus Protease Inhibitors Based on the 1-Oxo-1, 2, 3, 4-tetrahydroisoquinoline and 1-Oxo-1, 2-dihydroisoquinoline Scaffolds

The 1-Oxo-1, 2, 3, 4-tetrahydroisoquinoline and 1-Oxo-1, 2-dihydroisoquinoline scaffolds were utilized in the design and solution phase synthesis of focused libraries of compounds for screening against West Nile Virus (WNV) protease. Exploratory studies have lead to the identification of a WNV prote...

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Bibliografiske detaljer
Main Authors: Dou, Dengfeng, Viwanathan, Prasanth, Li, Yi, He, Guijia, Alliston, Kevin R., Lushington, Gerald H., Brown-Clay, Joshua D., Padmanabhan, R., Groutas, William C.
Format: Artigo
Sprog:Inglês
Udgivet: 2010
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2975906/
https://ncbi.nlm.nih.gov/pubmed/20882963
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cc100091h
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