Design, Synthesis and Characterization of Novel 1,2-Benzisothiazol-3(2H)-one and 1,3,4-Oxadiazole Hybrid Derivatives: Potent Inhibitors of Dengue and West Nile Virus NS2B/NS3 Proteases

1,2-Benzisothiazol-3(2H)-ones and 1,3,4-oxadiazoles individually have recently attracted considerable interest in drug discovery, including as antibacterial and antifungal agents. In this study, a series of functionalized 1,2-benzisothiazol-3(2H)-one - 1,3,4-oxadiazole hybrid derivatives were synthe...

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Main Authors: Lai, Huiguo, Dou, Dengfeng, Aravapalli, Sridhar, Teramoto, Tadahisa, Lushington, Gerald H., Mwania, Tom M., Alliston, Kevin R., Eichhorn, David M., Padmanabhan, R., Groutas, William C.
Format: Artigo
Jezik:Inglês
Izdano: 2012
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3563426/
https://ncbi.nlm.nih.gov/pubmed/23211969
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2012.10.058
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