Inhibition of Dengue Virus and West Nile Virus Proteases by Click Chemistry-Derived Benz[d]isothiazol-3(2H)-one Derivatives

Two click chemistry-derived focused libraries based on the benz[d]isothiazol-3(2H)-one scaffold were synthesized and screened against Dengue virus and West Nile virus NS2B-NS3 proteases. Several compounds (4l, 7j-n) displayed noteworthy inhibitory activity toward Dengue virus NS2B-NS3 protease in th...

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Main Authors: Tiew, Kok-Chuan, Dou, Dengfeng, Teramoto, Tadahisa, Lai, Huiguo, Alliston, Kevin R., Lushington, Gerald H., Padmanabhan, R., Groutas, William C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3279297/
https://ncbi.nlm.nih.gov/pubmed/22249124
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2011.12.047
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