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Inhibition of Dengue Virus and West Nile Virus Proteases by Click Chemistry-Derived Benz[d]isothiazol-3(2H)-one Derivatives
Two click chemistry-derived focused libraries based on the benz[d]isothiazol-3(2H)-one scaffold were synthesized and screened against Dengue virus and West Nile virus NS2B-NS3 proteases. Several compounds (4l, 7j-n) displayed noteworthy inhibitory activity toward Dengue virus NS2B-NS3 protease in th...
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| 主要な著者: | , , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2011
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| 主題: | |
| オンライン・アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3279297/ https://ncbi.nlm.nih.gov/pubmed/22249124 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2011.12.047 |
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