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Inhibition of Dengue Virus and West Nile Virus Proteases by Click Chemistry-Derived Benz[d]isothiazol-3(2H)-one Derivatives

Two click chemistry-derived focused libraries based on the benz[d]isothiazol-3(2H)-one scaffold were synthesized and screened against Dengue virus and West Nile virus NS2B-NS3 proteases. Several compounds (4l, 7j-n) displayed noteworthy inhibitory activity toward Dengue virus NS2B-NS3 protease in th...

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書誌詳細
主要な著者: Tiew, Kok-Chuan, Dou, Dengfeng, Teramoto, Tadahisa, Lai, Huiguo, Alliston, Kevin R., Lushington, Gerald H., Padmanabhan, R., Groutas, William C.
フォーマット: Artigo
言語:Inglês
出版事項: 2011
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3279297/
https://ncbi.nlm.nih.gov/pubmed/22249124
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2011.12.047
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