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Design, Synthesis and In Vitro Evaluation of Potential West Nile Virus Protease Inhibitors Based on the 1-Oxo-1, 2, 3, 4-tetrahydroisoquinoline and 1-Oxo-1, 2-dihydroisoquinoline Scaffolds

The 1-Oxo-1, 2, 3, 4-tetrahydroisoquinoline and 1-Oxo-1, 2-dihydroisoquinoline scaffolds were utilized in the design and solution phase synthesis of focused libraries of compounds for screening against West Nile Virus (WNV) protease. Exploratory studies have lead to the identification of a WNV prote...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
मुख्य लेखकों: Dou, Dengfeng, Viwanathan, Prasanth, Li, Yi, He, Guijia, Alliston, Kevin R., Lushington, Gerald H., Brown-Clay, Joshua D., Padmanabhan, R., Groutas, William C.
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: 2010
विषय:
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC2975906/
https://ncbi.nlm.nih.gov/pubmed/20882963
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cc100091h
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