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Design, Synthesis and In Vitro Evaluation of Potential West Nile Virus Protease Inhibitors Based on the 1-Oxo-1, 2, 3, 4-tetrahydroisoquinoline and 1-Oxo-1, 2-dihydroisoquinoline Scaffolds

The 1-Oxo-1, 2, 3, 4-tetrahydroisoquinoline and 1-Oxo-1, 2-dihydroisoquinoline scaffolds were utilized in the design and solution phase synthesis of focused libraries of compounds for screening against West Nile Virus (WNV) protease. Exploratory studies have lead to the identification of a WNV prote...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς: Dou, Dengfeng, Viwanathan, Prasanth, Li, Yi, He, Guijia, Alliston, Kevin R., Lushington, Gerald H., Brown-Clay, Joshua D., Padmanabhan, R., Groutas, William C.
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: 2010
Θέματα:
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2975906/
https://ncbi.nlm.nih.gov/pubmed/20882963
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cc100091h
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