Serotype-specific interactions among functional domains of dengue virus 2 nonstructural proteins (NS) 5 and NS3 are crucial for viral RNA replication

Four serotypes of mosquito-borne dengue virus (DENV), evolved from a common ancestor, are human pathogens of global significance for which there is no vaccine or antiviral drug available. The N-terminal domain of DENV NS5 has guanylyltransferase and methyltransferase (MTase), and the C-terminal regi...

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Bibliographic Details
Published in:J Biol Chem
Main Authors: Teramoto, Tadahisa, Balasubramanian, Anuradha, Choi, Kyung H., Padmanabhan, Radhakrishnan
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2017
Subjects:
Microbiology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5465476/
https://ncbi.nlm.nih.gov/pubmed/28396347
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.775643
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