Dengue Virus Nonstructural Protein 5 (NS5) Assembles into a Dimer with a Unique Methyltransferase and Polymerase Interface

Flavivirus nonstructural protein 5 (NS5) consists of methyltransferase (MTase) and RNA-dependent RNA polymerase (RdRp) domains, which catalyze 5’-RNA capping/methylation and RNA synthesis, respectively, during viral genome replication. Although the crystal structure of flavivirus NS5 is known, no da...

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Udgivet i:PLoS Pathog
Main Authors: Klema, Valerie J., Ye, Mengyi, Hindupur, Aditya, Teramoto, Tadahisa, Gottipati, Keerthi, Padmanabhan, Radhakrishnan, Choi, Kyung H.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2016
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4760774/
https://ncbi.nlm.nih.gov/pubmed/26895240
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1005451
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