Substitution of NS5 N-terminal Domain of Dengue Virus Type 2 RNA with Type 4 Domain Caused Impaired Replication and Emergence of Adaptive Mutants with Enhanced Fitness

Flavivirus NS3 and NS5 are required in viral replication and 5′-capping. NS3 has NS2B-dependent protease, RNA helicase, and 5′-RNA triphosphatase activities. NS5 has 5′-RNA methyltransferase (MT)/guanylyltransferase (GT) activities within the N-terminal 270 amino acids and the RNA-dependent RNA poly...

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Detalhes bibliográficos
Main Authors: Teramoto, Tadahisa, Boonyasuppayakorn, Siwaporn, Handley, Misty, Choi, Kyung H., Padmanabhan, Radhakrishnan
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2014
Assuntos:
RNA
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4139246/
https://ncbi.nlm.nih.gov/pubmed/24904061
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.584466
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