Phosphorylation Sites in the Hypervariable Domain in Chikungunya Virus nsP3 Are Crucial for Viral Replication

Chikungunya virus (CHIKV, family Togaviridae) is a mosquito-transmitted alphavirus. The positive-sense RNA genome of CHIKV encodes four nonstructural proteins (nsP1 to nsP4) that are virus-specific subunits of the RNA replicase. Among nsP functions, those of nsP3 are the least understood. The C-term...

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Bibliographic Details
Published in:J Virol
Main Authors: Teppor, Mona, Žusinaite, Eva, Merits, Andres
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2021
Subjects:
Genome Replication and Regulation of Viral Gene Expression
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8104096/
https://ncbi.nlm.nih.gov/pubmed/33568506
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02276-20
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