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N-Glycosyl Bond Formation Catalyzed by Human Alkyladenine DNA Glycosylase
The removal of damaged bases by DNA glycosylases is thought to be effectively irreversible, due to an overall equilibrium that favors hydrolysis over synthesis of the N-glycosyl bond. Surprisingly, human alkyladenine DNA glycosylase (AAG) can make damaged DNA by catalyzing N-glycosyl bond formation...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2975558/ https://ncbi.nlm.nih.gov/pubmed/20873830 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi101380d |
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