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Kinetic Mechanism for the Flipping and Excision of 1,N(6)-Ethenoadenine by Human Alkyladenine DNA Glycosylase
Human alkyladenine DNA glycosylase initiates the repair of a wide variety of alkylated and deaminated purine lesions in DNA. In this study we take advantage of the natural fluorescence of the 1,N(6)-ethenoadenosine (εA) lesion and report a kinetic analysis of binding, nucleotide flipping, base excis...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2792197/ https://ncbi.nlm.nih.gov/pubmed/19883114 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi9015082 |
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