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Distinguishing Specific and Nonspecific Complexes of Alkyladenine DNA Glycosylase
Human alkyladenine DNA glycosylase (AAG) recognizes many alkylated and deaminated purine lesions and excises them to initiate the base excision DNA repair pathway. AAG employs facilitated diffusion to rapidly scan nonspecific sites and locate rare sites of damage. Nonspecific DNA binding interaction...
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| Publicado en: | Biochemistry |
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| Autores principales: | , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2018
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6098249/ https://ncbi.nlm.nih.gov/pubmed/29940097 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.8b00531 |
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