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Search for DNA damage by human alkyladenine DNA glycosylase involves early intercalation by an aromatic residue
DNA repair enzymes recognize and remove damaged bases that are embedded in the duplex. To gain access, most enzymes use nucleotide flipping, whereby the target nucleotide is rotated 180° into the active site. In human alkyladenine DNA glycosylase (AAG), the enzyme that initiates base excision repair...
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| Publicado no: | J Biol Chem |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5625039/ https://ncbi.nlm.nih.gov/pubmed/28747435 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.782813 |
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