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ADAM17 is regulated by a rapid and reversible mechanism that controls access to its catalytic site
Protein ectodomain shedding is crucial for cell–cell interactions because it controls the bioavailability of soluble tumor necrosis factor-α (TNFα) and ligands of the epidermal growth factor (EGF) receptor, and the release of many other membrane proteins. Various stimuli can rapidly trigger ectodoma...
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| Autors principals: | , , , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Company of Biologists
2010
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2972273/ https://ncbi.nlm.nih.gov/pubmed/20980382 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.069997 |
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