Structural modeling defines transmembrane residues in ADAM17 that are crucial for Rhbdf2–ADAM17-dependent proteolysis

A disintegrin and metalloproteinase 17 (ADAM17) controls the release of the pro-inflammatory cytokine tumor necrosis factor α (TNFα, also known as TNF) and is crucial for protecting the skin and intestinal barrier by proteolytic activation of epidermal growth factor receptor (EGFR) ligands. The seve...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Cell Sci
Prif Awduron: Li, Xue, Maretzky, Thorsten, Perez-Aguilar, Jose Manuel, Monette, Sébastien, Weskamp, Gisela, Le Gall, Sylvain, Beutler, Bruce, Weinstein, Harel, Blobel, Carl P.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: The Company of Biologists Ltd 2017
Pynciau:
Research Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5358332/
https://ncbi.nlm.nih.gov/pubmed/28104813
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.196436
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