Structural modeling defines transmembrane residues in ADAM17 that are crucial for Rhbdf2–ADAM17-dependent proteolysis

A disintegrin and metalloproteinase 17 (ADAM17) controls the release of the pro-inflammatory cytokine tumor necrosis factor α (TNFα, also known as TNF) and is crucial for protecting the skin and intestinal barrier by proteolytic activation of epidermal growth factor receptor (EGFR) ligands. The seve...

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Detalhes bibliográficos
Publicado no:J Cell Sci
Main Authors: Li, Xue, Maretzky, Thorsten, Perez-Aguilar, Jose Manuel, Monette, Sébastien, Weskamp, Gisela, Le Gall, Sylvain, Beutler, Bruce, Weinstein, Harel, Blobel, Carl P.
Formato: Artigo
Idioma:Inglês
Publicado em: The Company of Biologists Ltd 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5358332/
https://ncbi.nlm.nih.gov/pubmed/28104813
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.196436
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