Targeted truncation of the ADAM17 cytoplasmic domain in mice results in protein destabilization and a hypomorphic phenotype

A disintegrin and metalloprotease 17 (ADAM17) is a cell-surface metalloprotease that serves as the principle sheddase for tumor necrosis factor α (TNFα), interleukin-6 receptor (IL-6R), and several ligands of the epidermal growth factor receptor (EGFR), regulating these crucial signaling pathways. A...

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Udgivet i:J Biol Chem
Main Authors: Lora, Jose, Weskamp, Gisela, Li, Thomas M., Maretzky, Thorsten, Shola, Dorjee T.N., Monette, Sébastien, Lichtenthaler, Stefan F., Lu, Theresa T., Yang, Chingwen, Blobel, Carl P.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2021
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8191336/
https://ncbi.nlm.nih.gov/pubmed/33957124
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jbc.2021.100733
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