ADAMs 10 and 17 Represent Differentially Regulated Components of a General Shedding Machinery for Membrane Proteins Such as Transforming Growth Factor α, L-Selectin, and Tumor Necrosis Factor α

Protein ectodomain shedding is a critical regulator of many membrane proteins, including epidermal growth factor receptor-ligands and tumor necrosis factor (TNF)-α, providing a strong incentive to define the responsible sheddases. Previous studies identified ADAM17 as principal sheddase for transfor...

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Main Authors: Le Gall, Sylvain M., Bobé, Pierre, Reiss, Karina, Horiuchi, Keisuke, Niu, Xiao-Da, Lundell, Daniel, Gibb, David R., Conrad, Daniel, Saftig, Paul, Blobel, Carl P.
Format: Artigo
Language:Inglês
Published: The American Society for Cell Biology 2009
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Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2655247/
https://ncbi.nlm.nih.gov/pubmed/19158376
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E08-11-1135
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