ADAM17 is regulated by a rapid and reversible mechanism that controls access to its catalytic site

Protein ectodomain shedding is crucial for cell–cell interactions because it controls the bioavailability of soluble tumor necrosis factor-α (TNFα) and ligands of the epidermal growth factor (EGF) receptor, and the release of many other membrane proteins. Various stimuli can rapidly trigger ectodoma...

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Detalhes bibliográficos
Main Authors: Le Gall, Sylvain M., Maretzky, Thorsten, Issuree, Priya D. A., Niu, Xiao-Da, Reiss, Karina, Saftig, Paul, Khokha, Rama, Lundell, Daniel, Blobel, Carl P.
Formato: Artigo
Idioma:Inglês
Publicado em: Company of Biologists 2010
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2972273/
https://ncbi.nlm.nih.gov/pubmed/20980382
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.069997
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