The oncogenic effect of sulfatase 2 (SULF2) in human hepatocellular carcinoma is mediated in part by glypican 3 (GPC3)-dependent Wnt activation

BACKGROUND & AIMS: Heparan sulfate proteoglycans (HSPGs) act as co-receptors or storage sites for growth factors and cytokines such as FGF and Wnts. Glypican 3 (GPC3) is the most highly expressed HSPG in hepatocellular carcinomas (HCCs). Sulfatase 2 (SULF2), an enzyme with 6-O desulfatase activi...

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Main Authors: Lai, Jin-Ping, Oseini, Abdul M, Moser, Catherine D, Yu, Chunrong, Elsawa, Sherine F, Hu, Chunling, Nakamura, Ikuo, Han, Tao, Aderca, Ileana, Isomoto, Hajime, Garrity-Park, Megan M, Shire, Abdirashid M, Li, Jia, Sanderson, Schuyler O, Adjei, Alex A, Fernandez-Zapico, Martin E, Roberts, Lewis R
Format: Artigo
Sprog:Inglês
Udgivet: 2010
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2967616/
https://ncbi.nlm.nih.gov/pubmed/20725905
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.23848
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