Sulfatase 2 protects hepatocellular carcinoma cells against apoptosis induced by the PI3K inhibitor LY294002 and ERK and JNK kinase inhibitors

BACKGROUND: Sulfatase 2 (SULF2), an extracellular heparan sulphate 6-O-endosulphatase, has an oncogenic effect in hepatocellular carcinoma (HCC) that is partially mediated through glypican 3, which promotes heparin-binding growth factor signalling and HCC cell growth. SULF2 also increases phosphoryl...

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Bibliografiske detaljer
Main Authors: Lai, Jin-Ping, Sandhu, Dalbir S., Yu, Chunrong, Moser, Catherine D., Hu, Chunling, Shire, Abdirashid M., Aderca, Ileana, Murphy, Linda M., Adjei, Alex A., Sanderson, Schuyler, Roberts, Lewis R.
Format: Artigo
Sprog:Inglês
Udgivet: 2010
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3042145/
https://ncbi.nlm.nih.gov/pubmed/21040406
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1478-3231.2010.02336.x
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