Hypermethylation of PTGER2 Confers Prostaglandin E(2) Resistance in Fibrotic Fibroblasts from Humans and Mice

Idiopathic pulmonary fibrosis (IPF) is a devastating lung disease that is characterized by excessive proliferation of fibroblasts. The lipid mediator prostaglandin E(2) (PGE(2)) has the capacity to limit fibrosis through its inhibition of numerous functions of these fibroblasts; however, in the sett...

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Detalhes bibliográficos
Main Authors: Huang, Steven K., Fisher, Aaron S., Scruggs, Anne M., White, Eric S., Hogaboam, Cory M., Richardson, Bruce C., Peters-Golden, Marc
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2010
Assuntos:
Regular Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2966784/
https://ncbi.nlm.nih.gov/pubmed/20889571
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2010.100446
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