Prostaglandin E(2) increases fibroblast gene-specific and global DNA methylation via increased DNA methyltransferase expression

Although alterations in DNA methylation patterns have been associated with specific diseases and environmental exposures, the mediators and signaling pathways that direct these changes remain understudied. The bioactive lipid mediator prostaglandin E(2) (PGE(2)) has been shown to exert a myriad of e...

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Autori principali: Huang, Steven K., Scruggs, Anne M., Donaghy, Jake, McEachin, Richard C., Fisher, Aaron S., Richardson, Bruce C., Peters-Golden, Marc
Natura: Artigo
Lingua:Inglês
Pubblicazione: Federation of American Societies for Experimental Biology 2012
Soggetti:
Research Communications
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3425823/
https://ncbi.nlm.nih.gov/pubmed/22645246
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.11-203323
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