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Plasmin Overcomes Resistance to Prostaglandin E(2) in Fibrotic Lung Fibroblasts by Reorganizing Protein Kinase A Signaling

Collagen deposition by fibroblasts contributes to scarring in fibrotic diseases. Activation of protein kinase A (PKA) by cAMP represents a pivotal brake on fibroblast activation, and the lipid mediator prostaglandin E(2) (PGE(2)) exerts its well known anti-fibrotic actions through cAMP signaling. Ho...

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Detalhes bibliográficos
Main Authors: Okunishi, Katsuhide, Sisson, Thomas H., Huang, Steven K., Hogaboam, Cory M., Simon, Richard H., Peters-Golden, Marc
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3173171/
https://ncbi.nlm.nih.gov/pubmed/21795691
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.235606
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