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Plasmin Overcomes Resistance to Prostaglandin E(2) in Fibrotic Lung Fibroblasts by Reorganizing Protein Kinase A Signaling
Collagen deposition by fibroblasts contributes to scarring in fibrotic diseases. Activation of protein kinase A (PKA) by cAMP represents a pivotal brake on fibroblast activation, and the lipid mediator prostaglandin E(2) (PGE(2)) exerts its well known anti-fibrotic actions through cAMP signaling. Ho...
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| Hoofdauteurs: | , , , , , |
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| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
American Society for Biochemistry and Molecular Biology
2011
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3173171/ https://ncbi.nlm.nih.gov/pubmed/21795691 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.235606 |
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